Hangzhou International School was founded in 2002 to serve foreign expatriate children in the beautiful city of Hangzhou, China. As an IB World School, HIS provides a rigorous, high-caliber academic program for students aged 2-18. HIS offers the International Early Years Curriculum (IEYC) for grades Nursery-Kindergarten, the International Primary Years Curriculum (IPC) for Grades 1-5, the International Middle Years Curriculum (IMYC) for Grades 6-8, and the International Baccalaureate Diploma Program (IBDP) for Grades 11-12. The school is accredited by the Western Association of Schools and Colleges (WASC) and is a member of the East Asia Regional Council of Schools (EARCOS) and the Association of China and Mongolia International Schools (ACAMIS). These associations and accrediting standards are recognized worldwide, which assures families that the HIS educational experience is of the highest standard for international schools and will be highly valued and transferable to their home countries or universities.best kindergarten in hangzhou

Currently, HIS serves almost 600 students from more than 30 nationalities. In addition to English and Mandarin, there are thirteen other best languages spoken by HIS students. For this reason, HIS includes significant learning specialist support. The school is especially proud of its continued recognition for language development and support.

The school continues to be ranked as one of the top IB international schools in Asia. In addition, HIS students continue to score well above international test measures while still providing a ‘complete’ learning experience within a rich and comprehensive extracurricular program, including visual arts, dance, music, design and computer technology, and athletics. HIS offers students a strong curricular experience with excellent opportunities to develop individual talents and areas of interest. All HIS students participate in IB Diploma Programme coursework. The graduating class of 2016 had a 100% pass rate for those registered as full IB Diploma candidates and exactly half of the students received a Bilingual IB Diploma (representing eight different languages). HIS Alumni have been accepted and offered full and partial scholarships to top universities in the United States, Canada, Australia, UK and other European countries.

A hallmark of HIS is the community-centered atmosphere, which welcomes participation within our community and with external partnerships. The HIS Parents and Friends Association (PAFA) actively supports student learning and commits significant time and energy in organizing events, decorating the campus on special occasions, and promoting guest presentations. HIS believes that only the best international schools devote their entire community to helping students, parents and faculty with transition. The HIS learning environment is safe, supportive and caring, which allows its students to develop soft skills of international mindedness, attain high levels of academic success, and pursue opportunities as leaders of the future. HIS students also participate in service and experiential learning, such as working with students at a school for the disabled or participating in the China Trips program. HIS graduates report high levels of preparedness for university and beyond. The school promotes the idea of students gaining the knowledge, skills, understandings, and attitudes to be ‘future ready’.

The HIS campus is conveniently located in the Binjiang High Tech Zone of Hangzhou, which recently hosted world leaders for the G20 Summit and is home to some of the key technology and manufacturing leaders, as well as strong economic development in light industry and tourism. This socio-economic environment allows HIS to develop 21st Century Learning skills and attitudes that will prepare students for the workplace of the future. HIS looks to promote learning that involves creativity, design, and innovation. The school is located in a suburban area and most students walk or ride their bicycle to school. This further allows HIS to serve as a community center for its students, parents, and faculty. Plans for the near future include a large complex that will include a large theater, gymnasium, swimming pool and visual and performing arts spaces.

Prestigious music school comes to tianjin

RETIRED after 34 years as president of New York’s Juilliard School, Joseph W. Polisi hasn’t abandoned his love of music education.

The 71-year-old bassoonist and music educator is ready to bring the renowned “Juilliard experience” to East Asia.international school in Tianjin

“Technique is not the goal of studying music, but rather artistry and communication,” said Polisi. “It is important for artistic students to not only excel in their majors, but also to advocate for art in their communities. “

Polisi, who retired last June, was recently appointed chief China officer to supervise development of the Tianjin Julliard School, scheduled to open in the autumn of 2019 in the northern Chinese city. It is being developed in cooperation with the Tianjin Conservatory of Music.

The Tianjin Julliard School, as the first and so-far only branch campus of the Julliard School in the world, will start with a pre-college program in the 2019 fall term, for students aged 8-18. It will be scheduled every Saturday and offers courses such as music theory, instruments and even chorus.

The school will expand in 2020 to include a graduate program offering master’s degree of music in orchestral performance, chamber music performance and collaborative piano.

Tuition, according to the school’s website, will be 87,500 yuan (US$13,060) for the re-college program. Tuition charges for graduate studies will be posted in the near future.

Word of the new school spread quickly. Within 24 hours after Tianjin Juilliard opened its application process last Thursday, the admissions office had received up to 20 inquiries about both the pre-college and graduate programs. So far, about 80 students have submitted preliminary information for applications.

The Tianjin Julliard School is a major component of Juilliard Global Ventures, which Polisi helped found in 2014. It aims to take the successful program of Julliard music education to more students worldwide.

“We are making an investment in China because we believe in it,” he said. “We are here to try to enhance the musical environment. We see ourselves as colleagues, rather than competitors.”Polisi was recently in Shanghai, sharing some of his plans for the Tianjin Julliard School.

International School of Tianjin Introduction

The International School of Tianjin (IST) was the first venue outside Beijing to host our children’s coaching programmes. Classes have been running at the school since Autumn 2009, and take place on the grass pitches at the school’s impressive campus in the Jinnan district, south of the city centre. Classes are available for players aged from Kindergarten (at least 4.5 years old) to Grade 8.Tianjin international school

As with many of ClubFootball’s school venues children who do not attend IST are welcome to join, however students who do go to the school will be given priority booking if courses are over-subscribed. Please click the links on the left for more specific details about the times and dates of Current or Upcoming Courses.

If you do decide to register, please be sure to read the Course Notes and pay particular attention to the school-specific rules listed. Before registering, please also read the notes on refunds and registration FAQ’s in the Register section in the toolbar at the top of the page.

Concordia International School Shanghai

Concordia International School Shanghai is a co-educational day school for students aged 3 to 18, located on a 10-acre campus in the heart of Jinqiao—one of Shanghai’s largest international communities. Known as the “green city,” with its many open green spaces and family-oriented amenities, Jinqiao is a destination for expatriate families from around the world.Shanghai international school

The school is recognized for its dedication to academic excellence and for providing well-developed sports, arts, service and cultural learning programs. Our caring, passionate and award-winning faculty deliver a comprehensive American curriculum and pioneer programs that guide individual students toward life success— no matter how they define it.

Life Success Starts with Concordia

Whether they are the youngest learners or soon-to-be graduates, Concordia students apply their learning to real-life challenges. Employing an applied-learning approach in purpose-built learning spaces, our passionate and talented teachers create and deliver authentic learning experiences that engage students and impact their lives forever.

“Concordia has some of the most caring and qualified teachers I have ever met. They set high standards for their students but also dedicate a lot of time to helping students succeed.” – Concordia Class of 2013 graduate

Start Your Journey in a Nurturing Environment

Rather than simply focusing on the development of a student’s intellect, we strive to develop the whole student in a unique global perspective. Encouraging fair play, good character and a heart for service is an important aspect of our holistic approach to education. And we believe a child’s education is a team effort among the parents, the student and the school. All parties work together to prepare students for their future.

“Our family loves Concordia dearly… in particular, my daughter. She receives great support, love and care from teachers and staff to excel in her education as well as help her grow into a good person. I’m confident she will maintain the core values Concordia helped her develop.” –Concordia parent, Thailand

Embrace Community at Concordia

Through a culture of involvement and interaction, our families connect. The diverse community, representing nearly thirty different nationalities, is proud to call Concordia home. The school, grounded in Christian values, is welcoming and supportive, allowing students and families to successfully transition to their new environment.

“We were worried about moving half a world away from our family and friends. But we felt welcomed and from day one. The boys have met and interacted with kids from all over the world. I had no idea the ease with which you can make new friends and establish a support system here in Shanghai.” -Concordia parent, USA

Concordia International School Shanghai—providing academic excellence, unlikely opportunity, and vibrant community that lays the foundation for the entire family’s success.

Palmitoylethanolamide powder holds potential as a CBD alternative

Regulatory confusion over cannabinoids (CBD) has opened up the space for alternatives, within which Gencor has released Levagen, a palmitoylethanolamide (PEA) ingredient touted as having anti-inflammatory and pain relief properties. The company also utilizes a novel delivery method coined LipiSperse that increases the bioavailability of its PEA ingredient and allows for applications such as shots and chews. “This opens up the market and allows consumers to be more familiar with PEA. It can add value to products within the sports nutrition space,” Mariko Hill, Product Development Executive at Gencor tells NutritionInsight, at Vitafoods, Geneva, earlier this month.Palmitoylethanolamide powder

PEA is produced in the body as a biological response and as a repair mechanism for inflammation. It is a simple fatty acid amide that is structurally related to the endogenous cannabinoid transmitter, anandamide (AEA). AEA is associated with regulating pain and the more AEA in the bloodstream, the less discomfort a person may feel. PEA has numerous clinical studies demonstrating its potential as an effective and safe anti-inflammatory, analgesic and tissue-protective nutrient.

CBD was early this year classified as an unauthorized novel food and regulatory limitations may curb NPD, especially in the pain relief relating to sports nutrition space, according to Hill. This is where Gencor’s Levagen PEA comes in as an alternative, which can eliminate regulatory hurdles, she says. “This leaves space for an alternative like PEA, more specifically our brand ingredient Levagen, which acts on those receptors that boost energy and have anti-inflammatory properties,” Hill notes.

However, this does not mean that PEA is just an alternative. In places where cannabinoids face no regulatory issues, PEA can be used in combination with CBD to boost health benefits. In places where CBD is allowed, PEA can work synergistically with it, as they target those same pathways,” Chase Shryoc, Gencor’s Vice President of Sales and Business Development, tells NutritionInsight.

“PEA is a fatty acid and an endogenous module, which can be found in every cell in the body. It is an endocannabinoid receptor agonist, which means that it works in the endocannabinoid system, similar to CBD. CBD binds directly to CB1 and CB2 receptor sites, while Levagen PEA indirectly activates those same receptors and has that same effect, but from a different direction,” Shyroc explains.

Hill adds that although PEA is an alternative, people should look at it as a completely different product to CBD. “It works synergistically because it is an endocannabinoid and is actually produced in the body endogenously as well. Supplementation can then offset that balance within the body and you can also use it in combination with CBD, but since CBD is still a novel food that may present challenges.”

Gencor is using a new delivery method called LipiSperse, that can boost Levagen’s properties. LipiSperse is a novel system tailored to increase the dispersion of crystalline lipophilic agents in aqueous environments. Cold water dispersible (CWD) powders have an equilibrium established between the LipiSperse on the powder surface and the LipiSperse in the solution, according to the company.

“So there is a Levagen standalone and one supported by LipiSperse, which we call Levagen+, a cold-water dispersible powder. This delivery technology increases the bioavailability and functionality of the ingredient. We also did a PEA study in which Levagen+ is showing 1,8 higher absorption to standalone PEA,” Hill notes. The new delivery method allows for a broader spectrum of applications for the ingredient.

Levagen for osteoarthritis
Adding to the list of benefits for the ingredient, a new study has found that Levagen may have a beneficial effect on knee osteoarthritis and support healthy aging. The study published in the Inflammopharmacology Journal, aimed to examine the safety, tolerability and efficacy of PEA when dosed at 300mg and 600mg per day on symptoms of knee osteoarthritis.

“Osteoarthritis is one of the most common joint related concerns caused by the breakdown of articular cartilage and remodeling of joint tissues driven by inflammatory mediators,” says R.V. Venkatesh, Managing Director at Gencor. “The results of this study demonstrated the effects of Levagen and its ability to not only reduce pain but its ability to reduce anxiety levels, according to the Depression Anxiety Stress Scales (DASS).”

The eight-week, double-blind randomized placebo-controlled study also concluded that Levagen may be a novel treatment for attenuating pain and reducing other associated symptoms of knee osteoarthritis at both 300mg and 600mg per day.

“PEA is unique due to its several fast-acting therapeutic effects,” notes Shryoc. “The study recipients reported a gradual reduction of WOMAC pain scores in just one week with further significant reductions at week 4 and 8. In addition to joint health, Levagen can also aid in restful sleep and recovery.”

According to the company, there are additional clinical studies taking place with Gencor’s Levagen which are expected to be released later this year. Gencor is also putting additional research into Levagen+.

Palmitoylethanolamide Powder | 30 Grams | Pea Powder

Palmitoylethanolamide is a fatty acid amide that is naturally present in our bodies. It mainly functions as a very comprehensive anti-inflammatory and pain reducer. In terms of pain reduction, it works great for individuals with neuropathic pain and produces significant back pain relief and sciatic pain relief. This is due to the fact that palmitoylethanolamide produces something called the ‘Entourage Effect’ an effect which potentiates the effects of Anandamide and it is naturally present in our bodies. Anandamide plays a crucial role in inflammation and pain perception, and Palmitoylethanolamide prevents the breakdown of anandamide and works to enhance its effects in the body. This pathway is especially effective at decreasing neuropathic pain and thus palmitoylethanolamide is very popular with people looking for sciatic pain relief and back pain relief.Palmitoylethanolamide

Palmitoylethanolamide also works to decrease inflammation by interacting with an enzyme called cyclooxygenase 2 (COX-2). This enzyme produces inflammation and is the target of most NSAIDs like Ibuprofen. These NSAIDs decrease pain perception by blocking COX-2 activity, whereas palmitoylethanolamide decreases pain perception by preventing the production of proinflammatory compounds that are produced by COX-2, such as prostaglandins D2 and E2.

Another unique effect that palmitoylethanolamide has, is that it activates the PPAR-alpha receptor. This receptor a major mediator of inflammation and pain perception and its activation causes a decrease in inflammation and a subsequent drop in pain perception.

Altogether, palmitoylethanolamide is a great compound for neuropathic pain and is a fantastic choice for individuals looking for sciatic pain relief and back pain relief.

*Attention: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Palmitoylethanolamide, also known as PEA, is a endogenous fatty acid amide that has been demonstrated to exert a great variety of biological functions related to pain. Additionally, it has been shown to have neuroprotective properties. Pain management support dates as far back as before 1980. The birth of the molecule was in 1957 and it was in that year that 5 researchers believed that PEA was a natural pain management supplement.

Where to buy Compound 7P powder (1890208-58-8) ?

Compound 7P powder is one of Neurotrophic drug. Axon regeneration after injury in the central nervous system is hampered in part because if an age-dependent decline in the intrinsic axon growth potential, and one of the strategies to stimulate axon growth in injured neurons involves pharmacological manipulation of implicated signaling pathways. Here we report phenotypic cell-based screen of chemical libraries and structure-activity-guided optimization that resulted in the identification of compound 7p which promotes neurite outgrowth of cultured primary neurons derived from the hippocampus, cerebral cortex, and retina. In an animal model of optic nerve injury, compound 7p was shown to induce growth of GAP-43 positive axons, indicating that the in vitro neurite outgrowth activity of compound 7p translates into stimulation of axon regeneration in vivo. Further optimization of compound 7p and elucidation of the mechanisms by which it elicits axon regeneration in vivo will provide a rational basis for future efforts to enhance treatment strategies.
We are a professional supplier of API in China, our Compound 7P with high quality and reasonable price. We are focused on providing our customers with the best service. Our high purity active ingredients is tested by HPLC.Compound 7P

Compound 7p exhibited 100% inhibition of parasitemia on day 4 at multiple doses(100, 50, and 25 mg/kg) given for four consecutive days, but at 100 mg/kg, all mice survived and were cured, while at 50 mg/kg, three of five mice survived and two mice were cured, and at 25 mg/kg, none of the mice survived

Reminyl (galantamine hydrobromide)

Reminyl is an Alzheimer’s treatment derived from the bulbs of the daffodil, Narcissus pseudonarcissus. It is believed that neurons producing the neurotransmitter acetylcholine degenerate in the brains of patients with Alzheimer’s disease. This loss of acetylcholine has been correlated with decreased cognitive function (thinking, remembering and reasoning). Reminyl works to increase the concentration of acetylcholine by blocking the action of acetylcholinesterase, an enzyme that catalyzes the hydrolysis (break down) of acetylcholine.Galantamine Hydrobromide powder

An estimated four million Americans have Alzheimer’s disease — a progressive loss of cognitive function so severe that it interferes with an individual’s ability to function. The number is expected to grow to 14 million by the middle of the next century. The disorder is the third-most expensive illness in the United States, behind only heart disease and cancer.

Reminyl was developed by the Janssen Research Foundation under a co-development and licensing agreement with the UK-based Shire Pharmaceuticals. The drug will be marketed by Janssen Pharmaceutica and Ortho-McNeil Pharmaceutical in the United States.

Clinical Results
In trials ranging from 12 to 26 weeks, the effectiveness of Reminyl was measured using two primary tools. Subjects’ abilities in terms of memory, orientation, reasoning and language were assessed using the cognitive portion of the Alzheimer’s Disease Assessment Scale (ADAS-cog). Across all trials, results demonstrated that more subjects taking Reminyl showed significant improvement in their cognitive performance than subjects taking placebo.

The second primary measure of effectiveness was the Clinician’s Interview-Based Impression of Change plus Caregiver Information (CIBIC-plus), which provides an overall assessment of patient functioning – including behavior, organized thinking and activities of daily living (such as dressing, eating and managing family finances). The CIBIC-plus results from all trials also showed that the overall scores for subjects taking Reminyl were statistically superior to placebo.
The most frequent adverse events associated with the use of Reminyl can be minimized by following the recommended dosage and administration.

Because this list is not all-inclusive, please consult a physician to discuss any side effects and the individual appropriateness of the drug.

Mechanism of Action
Galantamine, a tertiary alkaloid, is a competitive and reversible inhibitor of acetylcholinesterase. While the precise mechanism of galantamine’s action is unknown, it may exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by cholinesterase. If this mechanism is correct, galantamine’s effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. (from Reminyl Prescribing Information).

Nicotinomide Riboside Linked To Proxy For Healthier Aging In Pilot Study

In a small pilot study consume who consumed a natural dietary supplement called nicotinomide riboside (NR) daily showed signs of mimicking caloric restriction, which in mice has been linked to health benefits.Nicotinamide Riboside Chloride powder

Caloric restriction is a starvation diet. When lower level organisms such as fruit flies, roundworms, rodents are raised on such a diet from birth, slashing of caloric intake by about a third has health benefits and, in some cases, extended lifespan. No humans have done that, it would be a human rights violation to wean a baby on a starvation diet, and claims about benefits in adults who took it up have too many confounders to be anything more than anecdotes.

In a small pilot study, 12 lean and healthy men and women ages 55 to 79 from the Boulder area were given a placebo for six weeks, then took a 500 mg twice-daily dose of nicotinamide riboside chloride (NIAGEN). Another 12 took nicotinamide riboside for the first six weeks, followed by placebo. The researchers took blood samples and other physiological measurements at the end of each treatment period. They found that the supplement slightly improved blood pressure and arterial health, particularly in those with mild hypertension but what they wanted to find was that 1,000 mg daily of nicotinamide riboside boosted levels of another compound called nicotinamide adenine dinucleotide (NAD+) by 60 percent. NAD+ is required for activation of enzymes called sirtuins, which is hypothesized to be involved in the beneficial effects of calorie restriction. It’s involved in a host of metabolic actions throughout the body, and tends to decline with age.

Some suggest that as an evolutionary survival mechanism, the body conserves NAD+ when subjected to calorie restriction and that led to the idea of supplementing with so-called “NAD+-precursors” like nicotinamide riboside to promote healthier aging.

The pilot study also found that in 13 participants with elevated blood pressure or stage 1 hypertension (120-139/80-89 mmHg), systolic blood pressure was about 10 points lower after supplementation. A drop of that magnitude could translate to a 25 percent reduction in heart attack risk but this is a pilot study in healthy people, so it should only be considered a viable technique if a company is willing to enter it into clinical trials. Otherwise, it will remain just another supplement for people who want to believe.

First human clinical trial for nicotinamide riboside

In the first controlled clinical trial of nicotinamide riboside (NR), a newly discovered form of Vitamin B3, researchers have shown that the compound is safe for humans and increases levels of a cell metabolite that is critical for cellular energy production and protection against stress and DNA damage.Nootropics Powder

Studies in mice have shown that boosting the levels of this cell metabolite—known as NAD+—can produce multiple health benefits, including resistance to weight gain, improved control of blood sugar and cholesterol, reduced nerve damage, and longer lifespan. Levels of NAD+ diminish with age, and it has been suggested that loss of this metabolite may play a role in age-related health decline.

These findings in animal studies have spurred people to take commercially available NR supplements designed to boost NAD+. However, these over-the-counter supplements have not undergone clinical trials to see if they work in people.

The new research, reported Oct. 10 in the journal Nature Communications, was led by Charles Brenner, PhD, professor and Roy J. Carver Chair of Biochemistry at the University of Iowa Carver College of Medicine in collaboration with colleagues at Queens University Belfast and ChromaDex Corp. (NASDAQ: CDXC), which supplied the NR used in the trial. Brenner is a consultant for ChromaDex. He also is co-founder and Chief Scientific Adviser of ProHealthspan, which sells NR supplements under the trade name Tru NIAGEN®.

The human trial involved six men and six women, all healthy. Each participant received single oral doses of 100 mg, 300 mg, or 1,000 mg of NR in a different sequence with a seven-day gap between doses. After each dose, blood and urine samples were collected and analyzed by Brenner’s lab to measure various NAD+ metabolites in a process called metabolomics. The trial showed that the NR vitamin increased NAD+ metabolism by amounts directly related to the dose, and there were no serious side effects with any of the doses.

“This trial shows that oral NR safely boosts human NAD+ metabolism,” Brenner says. “We are excited because everything we are learning from animal systems indicates that the effectiveness of NR depends on preserving and/or boosting NAD+ and related compounds in the face of metabolic stresses. Because the levels of supplementation in mice that produce beneficial effects are achievable in people, it appears than health benefits of NR will be translatable to humans safely.”

The next step will be to study the effect of longer duration NR supplementation on NAD+ metabolism in healthy adults, but Brenner also has plans to test the effects of NR in people with diseases and health conditions, including elevated cholesterol, obesity and diabetes, and people at risk for chemotherapeutic peripheral neuropathy.